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© Perrine Bomme, Guillaume Duménil, Jean-Marc Panaud.
Coloured scanning electron micrograph (SEM) of Neisseria meningitidis on epithelial cells
Publication : Vaccine

Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vaccine - 12 Jul 2013

Delbos V, Lemée L, Bénichou J, Berthelot G, Deghmane AE, Leroy JP, Houivet E, Hong E, Taha MK, Caron F,

Link to Pubmed [PMID] – 23856330

Vaccine 2013 Sep;31(40):4416-20

The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there were 17 Neisseria meningitidis carriers (carriage rate of 1.57%). MenBvac vaccination appeared associated with lower carriage rate, i.e., 0.31% among the vaccinated children versus 2.10% among the non-vaccinated (p=0.03). The beneficial effect on carriage was observed regardless of the strain serogroup. OMV-vaccinated mice also showed reduction of bacterial acquisition of OMV-homolog and hererolog strains in respiratory pathways after intranasal challenge. These results suggest that meningococcal OMV-based vaccines reduce meningococcal carriage and may hence confer herd immunity.

https://www.ncbi.nlm.nih.gov/pubmed/23856330