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© Charles Dauguet
Virus VIH-1 (HIV-1), agent du sida, à la surface d'un lymphocyte. Image colorisée.
Publication : Journal of reproductive immunology

Immunoactive products of human placenta. II. Direct inhibition of non-MHC restricted cytolytic activity of human CD3 alpha-beta but not CD3 gamma-delta expressing T cell clones

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of reproductive immunology - 01 Nov 1989

Menu E, David V, Bensussan A, Chaouat G

Link to Pubmed [PMID] – 2532256

J. Reprod. Immunol. 1989 Nov;16(2):137-50

The effect of human placental supernatant obtained from explant cultures of caesarean delivery placentae was monitored on both alpha-beta human T cell clones, which display both cytotoxic alloreactivity and non-MHC restricted cytotoxicity against K562 target cells, and gamma-delta ones endowed solely with the latter. It was found that, under appropriate experimental conditions, direct inhibition of the cytolytic activity of alpha-beta T cell clones was exerted by the supernatant. In contrast, gamma-delta T cell clones were unaffected. The relevance of these data to the survival of the fetal allograft is discussed.

http://www.ncbi.nlm.nih.gov/pubmed/2532256