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© Research
Publication : Vaccine

Immune responses to hybrid maltose-binding proteins

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vaccine - 01 Jan 1993

O'Callaghan D, Martineau P, Fayolle C, Leclerc C, Guillet JG, Charbit A, Hofnung M

Link to Pubmed [PMID] – 7679863

Vaccine 1993;11(2):140-2

The Escherichia coli maltose-binding protein is a highly versatile carrier protein allowing the construction of genetically engineered hybrid proteins. It accepts large fusions to both C- and N-termini as well as the insertion of shorter peptides at ‘permissive sites’ within the continuity of the protein. We have genetically inserted immunogenic peptides corresponding to defined viral B- and T-cell epitopes into two permissive sites: one at amino acid site 133, the other at site 303. The hybrid proteins are easily purifiable and immunogenic, inducing peptide-specific B- and T-cell responses. When delivered by live bacteria (E. coli K12 and aroA Salmonella typhimurium) antibody responses can be induced against both the MalE carrier and the inserted B-cell epitope. We discuss the induction of T-cell responses by bacterial delivery systems.

http://www.ncbi.nlm.nih.gov/pubmed/7679863