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© Research
Publication : European journal of immunology

Immune response against poly(Glu60,Ala30,Tyr10) (GAT): immunization with monoclonal anti-idiotypic antibodies leads to the predominant stimulation of idiotypically similar immunoglobulins with anti-GAT activity

Team: Ecology and Emergence of Arthropod-borne Pathogens
Member: Claude Roth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Jun 1985

Roth C, Sommé G, Schiff C, Thèze J

Link to Pubmed [PMID] – 3874070

Eur. J. Immunol. 1985 Jun;15(6):576-80

Two monoclonal anti-idiotypic antibodies (HP-Id20 and HP-Id22) recognizing two different public idiotopes expressed in the anti-poly(Glu60,Ala30,Tyr10) (GAT) response were used to immunize BALB/c and C57BL/6 mice. From these animals hybridomas were isolated. From BALB/c and C57BL/6 mice eight and seven monoclonal antibodies were characterized, respectively. The reagents were classified according to the expression of the public idiotypic specificity p.GAT (recognized by a rabbit antiserum). The anti-GAT activity and the expression of the various idiotopes characterized on anti-GAT polyclonal and monoclonal antibodies were also studied. Most of the reagents are Ab1′-type of antibody resembling anti-GAT antibodies. One anti-anti-idiotypic monoclonal antibody (Ab3) was also isolated from BALB/c mice. This suggests that in this experimental model the repertoire induced after HP-Id immunization and antigen stimulation is comparable. The idiotypic analysis of a large number of anti-GAT and of Ab1′ monoclonal antibodies suggests that only two public idiotopes are involved in the anti-GAT response.