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© Charles Dauguet
Virus VIH-1 (HIV-1), agent du sida, à la surface d'un lymphocyte. Image colorisée.
Publication : Journal of immunology (Baltimore, Md. : 1950)

IL-7 stimulates T cell renewal without increasing viral replication in simian immunodeficiency virus-infected macaques

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2003

Nugeyre MT, Monceaux V, Beq S, Cumont MC, Ho Tsong Fang R, Chêne L, Morre M, Barré-Sinoussi F, Hurtrel B, Israël N

Link to Pubmed [PMID] – 14530372

J. Immunol. 2003 Oct;171(8):4447-53

The main failure of antiretroviral therapy is the lack of restoration of HIV-specific CD4(+) T cells. IL-7, which has been shown to be a crucial cytokine for thymopoiesis, has been envisaged as an additive therapeutic strategy. However, in vitro studies suggest that IL-7 might sustain HIV replication in thymocytes and T lymphocytes. Therefore, in the present study, we evaluated the effect of IL-7 on both T cell renewal and viral load in SIVmac-infected young macaques in the absence of antiretroviral therapy. This evaluation was conducted during the asymptomatic phase in view of a potential treatment of HIV patients. We show that IL-7 induces both a central renewal and a peripheral expansion of T lymphocytes associated with cell activation. No alarming modulation of the other hemopoietic cells was observed. No increase in the viral load was shown in blood or lymph nodes. These data strengthen the rationale for the use of IL-7 as an efficient immunotherapy in AIDS.

http://www.ncbi.nlm.nih.gov/pubmed/14530372