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© Charles Dauguet
Virus VIH-1 (HIV-1), responsable du sida. Première étape de pénétration dans la cellule. Le virus s'approche du lymphocyte T4 et arrive à proximité de son point d'ancrage le récepteur CD4 qui reconnaît spécifiquement la protéine d'enveloppe virale gp120. On voit nettement le manteau de clathrine qui participe au processus d'endocytose (Grossissement X 190000). Image colorisée.
Publication : Experimental cell research

IFN-α and TRAIL: a double edge sword in HIV-1 disease?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Experimental cell research - 26 Mar 2012

Gougeon ML, Herbeuval JP

Link to Pubmed [PMID] – 22480868

Exp. Cell Res. 2012 Jul;318(11):1260-8

IFN-α is rapidly upregulated in response to viral infections and it is an essential player in innate immunity against viruses. pDCs are the most potent IFN-α-producing cells and serve as an essential link between innate and adaptive immunity. The fate of pDCs in the course of HIV-1 infection is still a matter of debate, and the question of the detrimental role of chronic production of IFN-α remains open. In particular, IFN-α has been shown to induce the expression of the death ligand TRAIL on pDCs, transforming them into killer pDCs that may contribute to the destruction of CD4(+) T cells, the hallmark of HIV-1-induced disease. In this review, we discuss our current understanding of the protective and pathogenic roles of both IFN-α and TRAIL in HIV-1 disease.

http://www.ncbi.nlm.nih.gov/pubmed/22480868