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© Charles DAUGUET, Institut Pasteur
HIV particles
Publication : Science (New York, N.Y.)

Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry

Team: Archived: Viral Pathogenesis
Member: Anne Brelot
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 20 Jun 1997

Pleskoff O, Tréboute C, Brelot A, Heveker N, Seman M, Alizon M

Link to Pubmed [PMID] – 9188536

Science 1997 Jun;276(5320):1874-8

The human cytomegalovirus encodes a beta-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.