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© Research
Publication : Journal of neurochemistry

How important are Rho GTPases in neurosecretion?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of neurochemistry - 01 Apr 2011

Momboisse F, Houy S, Ory S, Calco V, Bader MF, Gasman S

Link to Pubmed [PMID] – 21392006

J. Neurochem. 2011 May;117(4):623-31

Rho GTPases are small GTP binding proteins belonging to the Ras superfamily which act as molecular switches that regulate many cellular function including cell morphology, cell to cell interaction, cell migration and adhesion. In neuronal cells, Rho GTPases have been proposed to regulate neuronal development and synaptic plasticity. However, the role of Rho GTPases in neurosecretion is poorly documented. In this review, we discuss data that highlight the importance of Rho GTPases and their regulators into the control of neurotransmitter and hormone release in neurons and neuroendocrine cells, respectively.

http://www.ncbi.nlm.nih.gov/pubmed/21392006