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© Research
Publication : Trends in parasitology

Host cell invasion by apicomplexans: what do we know?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in parasitology - 10 Feb 2012

Bargieri D, Lagal V, Tardieux I, Ménard R

Link to Pubmed [PMID] – 22326913

Trends Parasitol. 2012 Apr;28(4):131-5

Apicomplexan zoites enter host cells by forming and actively moving through a tight junction (TJ) formed between the parasite and host cell surfaces. Although the TJ was first described decades ago, its molecular characterization has proved difficult mainly because of its transient existence during an internalization process that lasts only seconds. In the past 7 years, work has led to a model of the TJ in which the association between AMA1 and RON proteins structures the TJ and bridges the cytoskeletons of the two cells. However, more recent work questions this view. Here, we critically discuss the current model and speculate on alternative models of the AMA1-RON association and of the apicomplexan TJ.

http://www.ncbi.nlm.nih.gov/pubmed/22326913