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© Research
Publication : Science (New York, N.Y.)

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI

Team: Group: Humoral Immunity
Member: Paulo Vieira
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 01 Jun 1990

Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR

Link to Pubmed [PMID] – 2161559

Science 1990 Jun;248(4960):1230-4

Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.