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© Research
Publication : PloS one

HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 31 Oct 2008

Saïdi H, Melki MT, Gougeon ML

Link to Pubmed [PMID] – 18974890

PLoS ONE 2008;3(10):e3601

HIV-1 has evolved ways to exploit DCs, thereby facilitating viral dissemination and allowing evasion of antiviral immunity. Recently, the fate of DCs has been found to be extremely dependent on the interaction with autologous NK cells, but the mechanisms by which NK-DC interaction controls viral infections remain unclear. Here, we investigate the impact of NK-DC cross-talk on maturation and functions of HIV-infected immature DCs.

http://www.ncbi.nlm.nih.gov/pubmed/18974890