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© Fabrice Chrétien with Ultrapole, colorized by Jean-Marc Panaud
Cellule souche (en jaune) de muscle squelettique partiellement recouverte par la membrane basale, migrant sur une fibre musculaire (en bleu).
Publication : The American journal of surgical pathology

Histopathologic and ultrastructural features and claudin expression in papillary tumors of the pineal region: a multicenter analysis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The American journal of surgical pathology - 01 Jun 2012

Fèvre Montange M, Vasiljevic A, Bergemer Fouquet AM, Bernier M, Champier J, Chrétien F, Figarella-Branger D, Kemeny JL, Lechapt-Zalcman E, Michalak S, Miquel C, Mokthari K, Pommepuy I, Quintin Roué I, Rousseau A, Saint-Pierre G, Salon C, Uro-Coste E, Varlet P, Kratzer I, Ghersi-Egea JF, Jouvet A

Link to Pubmed [PMID] – 22588068

Am. J. Surg. Pathol. 2012 Jun;36(6):916-28

Neuroepithelial papillary tumor of the pineal region (PTPR) has been defined as a distinct entity that is increasingly being recognized, with 96 cases now reported. This tumor shares morphologic features with both ependymomas and choroid plexus tumors. PTPR is characterized by an epithelial-like growth pattern in which the vessels are covered by layers of tumor cells forming perivascular pseudorosettes. These tumors exhibit various combinations of papillary and solid architecture, making the differential diagnosis of PTPR difficult to establish. We report the detailed description of the histopathologic features of a large series of PTPRs from 20 different centers and distinguish 2 subgroups of tumors with either a striking papillary growth pattern or a papillary and solid growth pattern. We highlight the findings that PTPRs have unusual vessels with multiple lumina and frequently show detachment of the border of the tumoral cells from the vascular wall. The 2 PTPR subgroups present similar clinical characteristics and immunophenotypes. We confirmed and extended the results of previous ultrastructural studies on the presence of intercellular junctions at the apical part of tumoral cells. The expression of the tight junction proteins claudin-1, claudin-2, and claudin-3 was investigated by immunohistochemistry. Claudin-1 and claudin-3, but not claudin-2, were expressed in PTPRs and in the fetal subcommissural organ, potentially the origin of this tumor. In contrast, all 3 claudins were expressed in choroid plexus papillomas. Claudin expression may help in the diagnosis of PTPRs and can be used in combination with other markers, such as CK18, NCAM, E-cadherin, MAP-2, and Kir 7.1.

http://www.ncbi.nlm.nih.gov/pubmed/22588068