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© Research
Publication : Malaria journal

Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Malaria journal - 23 Mar 2010

White MT, Griffin JT, Drakeley CJ, Ghani AC

Link to Pubmed [PMID] – 20331863

Malar. J. 2010 Mar;9:82

BACKGROUND: Phase III trials of the malaria vaccine, RTS, S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias estimates of vaccine efficacy.

METHODS: Theoretical arguments are used to identify the expected effects of a) heterogeneity in exposure to infectious bites; b) heterogeneity in individual’s response to the vaccine; and c) waning efficacy on measures of vaccine efficacy from clinical trials for an infection-blocking vaccine.

RESULTS: Heterogeneity in exposure and vaccine response leads to a smaller proportion of trial participants becoming infected than one would expect in a homogeneous setting. This causes estimates of vaccine efficacy from clinical trials to be underestimated if transmission heterogeneity is ignored, and overestimated if heterogeneity in vaccine response is ignored. Waning of vaccine efficacy can bias estimates of vaccine efficacy in both directions.

CONCLUSIONS: Failure to account for heterogeneities in exposure and response, and waning of efficacy in clinical trials can lead to biased estimates of malaria vaccine efficacy. Appropriate methods to reduce these biases need to be used to ensure accurate interpretation and comparability between trial sites of results from the upcoming Phase III clinical trials of RTS, S.

https://www.ncbi.nlm.nih.gov/pubmed/20331863