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© Research
Publication : Transplantation

Hepatitis C virus-related fibrosing cholestatic hepatitis after renal transplantation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Transplantation - 15 Jan 1997

Zylberberg H, Carnot F, Mamzer MF, Blancho G, Legendre C, Pol S

Link to Pubmed [PMID] – 9000679

Transplantation 1997 Jan;63(1):158-60

Fibrosing cholestatic hepatitis is a well-described syndrome in patients with immunodeficiency and chronic hepatitis B. It is clinically, biologically, and histologically characterized by rapidly progressive hepatic failure, a mildly elevated serum aminotransferase level, an extensive periportal fibrosis associated with intense cholestasis, mild inflammatory cellular infiltrate, no cirrhosis, and a high hepatocellular level expression of B viral antigens. This syndrome reflected a direct hepatocytopathic injury linked to high intrahepatic viral antigen expression. Because the syndrome of fibrosing cholestatic hepatitis has not been described in chronic hepatitis C, we report the first well-characterized case in a renal transplant patient with chronic hepatitis C and discuss the clinical and pathogenic implications of such a syndrome in this setting.

https://www.ncbi.nlm.nih.gov/pubmed/9000679