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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Bulletin of the World Health Organization

Hepatic phase of malaria: a crucial role as “go-between” with other stages

Team: Biology of Host-parasite Interactions
Member: Denise Mattei
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Bulletin of the World Health Organization - 01 Jan 1990

Mazier D, Goma J, Pied S, Renia L, Nussler A, Miltgen F, Mattei D, Grau G

Link to Pubmed [PMID] – 2151269

Bull. World Health Organ. 1990;68 Suppl:126-31

Besides potential interest in itself, the hepatic stage of malaria might play a crucial role as “go-between” with other stages. When present in the parasitophorous vacuole, antibodies induced by both sporozoite and erythrocytic stages efficiently disturb hepatic development of the parasite. Likewise previous and ensuing erythrocytic stages can modulate the “shielded” phase by cytokines, directly or as a result of a cascade of events, and by MHC-restricted or antibody-dependent cytotoxic mechanisms.