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© Research
Publication : International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

HBsAg prevalence and the rates of mother-to-child transmission of hepatitis B virus following the introduction of infant vaccination programmes in South East Asia and Western Pacific regions: a systematic review.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 08 Sep 2022

Marjenberg Z, Wright C, Pooley N, Cheung KW, Shimakawa Y, Vargas-Zambrano JC, Vidor E,

Link to Pubmed [PMID] – 36089151

Link to DOI – S1201-9712(22)00503-310.1016/j.ijid.2022.09.003

Int J Infect Dis 2022 Sep; ():

Infant vaccination against hepatitis B virus (HBV) began in the World Health Organization (WHO) South East Asia Region (SEAR) and the Western Pacific Region (WPR) between 1983-2016. This systematic review examined seroprevalence of hepatitis B surface antigen (HBsAg) in children, and rate of mother-to-child transmission (MTCT) in these regions between 1990-2020.MEDLINE and EMBASE were searched for articles published between January 1990 and September 2020 which reported seroprevalence of HBsAg in children aged 0-15 years and/or rate of MTCT, in SEAR and WPR. A pragmatic review identified supporting information. This review was registered in PROSPERO (#CRD42020211707).Of 115 included studies, 77 (24 countries) reported HBsAg prevalence and 38 (nine countries) reported MTCT. Seroprevalence of HBsAg ranged between 0.0%-27.4%, with a decreasing trend over time in each country. MTCT rates were 0.0%-5.2% in infants of hepatitis B e antigen (HBeAg)-negative mothers, and 2.7%-53.0% in infants of HBeAg-positive mothers.Following the introduction of infant HBV vaccination programmes, the countries in SEAR and WPR observed a reduction in HBsAg seroprevalence in children. Nevertheless, the risk of MTCT persists, emphasising the importance of antenatal screening to identify high-risk pregnancies.

https://pubmed.ncbi.nlm.nih.gov/36089151