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© Research
Publication : Frontiers in immunology

Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches.

Team: Dendritic cells and adaptive immunity
Member: Pierre Guermonprez
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Frontiers in immunology - 01 Jan 2021

Pievani A, Savoldelli R, Poelchen J, Mattioli E, Anselmi G, Girardot A, Utikal J, Bourdely P, Serafini M, Guermonprez P

Link to Pubmed [PMID] – 33790904

Link to DOI – 10.3389/fimmu.2021.631279

Front Immunol 2021 ; 12(): 631279

Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance, and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both in vitro and in vivo.