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© Research
Publication : Applied and environmental microbiology

Glycosylphosphatidylinositol-anchored Ecm33p influences conidial cell wall biosynthesis in Aspergillus fumigatus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Applied and environmental microbiology - 01 May 2006

Chabane S, Sarfati J, Ibrahim-Granet O, Du C, Schmidt C, Mouyna I, Prevost MC, Calderone R, Latgé JP

Link to Pubmed [PMID] – 16672465

Appl. Environ. Microbiol. 2006 May;72(5):3259-67

ECM33 encodes a glycosylphosphatidylinositol-anchored protein whose orthologs in yeast are essential for sporulation. Aspergillus fumigatus Ecm33p is unique and has an apparent mass of 55 kDa. Disruption of A. fumigatus ECM33 results in a mutant with several morphogenetic aberrations, including the following: (i) a defect in conidial separation, (ii) an increase in the diameter of the conidia of the mutant associated with an increase in the concentration of the cell wall chitin, (iii) conidia that were sensitive to the absence of aeration during long-term storage, and (iv) conidia that were more resistant to killing by phagocytes, whereas the mycelium was more easily killed by neutrophils.

http://www.ncbi.nlm.nih.gov/pubmed/16672465