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© Research
Publication : Mutation Research

Genomic stability during cellular reprogramming: Mission impossible? Mutat Res. 2016 Jun;788:12-6,

Team: Cellular plasticity in age-related pathologies
Member: Mathieu von Joest
Member: Sabela Bua Aguin
Member: Han Li
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Mutation Research - 01 Jun 2016

von Joest M1, Búa Aguín S1, Li H2.

Link to Pubmed [PMID] – 26851988

Mutat Res. 2016 Jun;788:12-6

The generation of induced pluripotent stem cells (iPSCs) from adult somatic cells is one of the most exciting discoveries in recent biomedical research. It holds tremendous potential in drug discovery and regenerative medicine. However, a series of reports highlighting genomic instability in iPSCs raises concerns about their clinical application. Although the mechanisms cause genomic instability during cellular reprogramming are largely unknown, several potential sources have been suggested. This review summarizes current knowledge on this active research field and discusses the latest efforts to alleviate the genomic insults during cellular reprogramming to generate iPSCs with enhanced quality and safety.