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© Research
Publication : Proceedings of the National Academy of Sciences of the United States of America

Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2011

del Barco Barrantes I, Coya JM, Maina F, Arthur JS, Nebreda AR

Link to Pubmed [PMID] – 21768366

Proc. Natl. Acad. Sci. U.S.A. 2011 Aug;108(31):12764-9

p38α MAPK is an important regulator of cellular responses induced by external cues, but the elucidation of physiological functions for p38α has been complicated by the possible functional redundancy in vivo with the related family member p38β. We found that mice with combined deletion of p38α and p38β display diverse developmental defects at midgestation, including major cardiovascular abnormalities, which are observed neither in single knockout nor in double heterozygous embryos. Expression analysis indicates specific functions of p38α and p38β in the regulation of cardiac gene expression during development. By using knock-in animals that express p38β under control of the endogenous p38α promoter, we also found that p38β cannot perform all of the functions of p38α during embryogenesis. Our results identify essential roles for p38α and p38β during development and suggest that some specific functions may be explained by differences in expression patterns.

http://www.ncbi.nlm.nih.gov/pubmed/21768366