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© Research
Publication : Molecules (Basel, Switzerland)

Generation of Aptamers with an Expanded Chemical Repertoire

Team: Bioorganic chemistry of nucleic acids
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecules (Basel, Switzerland) - 14 Sep 2015

Diafa S, Hollenstein M

Link to Pubmed [PMID] – 26389865

Molecules 2015;20(9):16643-71

The enzymatic co-polymerization of modified nucleoside triphosphates (dN*TPs and N*TPs) is a versatile method for the expansion and exploration of expanded chemical space in SELEX and related combinatorial methods of in vitro selection. This strategy can be exploited to generate aptamers with improved or hitherto unknown properties. In this review, we discuss the nature of the functionalities appended to nucleoside triphosphates and their impact on selection experiments. The properties of the resulting modified aptamers will be described, particularly those integrated in the fields of biomolecular diagnostics, therapeutics, and in the expansion of genetic systems (XNAs).