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© Research
Publication : Seminars in cell & developmental biology

Gene regulation at a distance: from remote enhancers to 3D regulatory ensembles

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Seminars in cell & developmental biology - 27 Jun 2016

Spitz F

Link to Pubmed [PMID] – 27364700

Semin. Cell Dev. Biol. 2016 Jun;

Large-scale identification of elements associated with gene expression revealed that many of them are located extremely far from gene transcriptional start sites. We review here the growing evidence that show that distal cis-acting elements provide key instructions to genes, as genetic variation affecting them is growingly identified as an importance source of phenotypic diversity and disease. We discuss the different mechanisms that allow these elements to exert their regulatory functions, in a robust and specific manner, despite the large genomic distances separating them from their target genes. We particularly focus on the role of the structural organization of the genome in guiding such regulatory interactions.

http://www.ncbi.nlm.nih.gov/pubmed/27364700