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© Research
Publication : Current opinion in lipidology

Gene-gene and gene-environment interactions defining lipid-related traits.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in lipidology - 01 Apr 2011

Ordovás JM, Robertson R, Cléirigh EN,

Link to Pubmed [PMID] – 21311326

Link to DOI – 10.1097/MOL.0b013e32834477a9

Curr Opin Lipidol 2011 Apr; 22(2): 129-36

Steps towards reducing chronic disease progression are continuously being taken through the form of genomic research. Studies over the last year have highlighted more and more polymorphisms, pathways and interactions responsible for metabolic disorders such as cardiovascular disease, obesity and dyslipidemia.Many of these chronic illnesses can be partially blamed by altered lipid metabolism, combined with individual genetic components. Critical evaluation and comparison of these recent studies is essential in order to comprehend the results, conclusions and future prospects in the field of genomics as a whole. Recent literature elucidates significant gene–diet and gene–environment interactions resulting in altered lipid metabolism, inflammation and other metabolic imbalances leading to cardiovascular disease and obesity.Epigenetic and epistatic interactions are now becoming more significantly associated with such disorders, as genomic research digs deeper into the complex nature of genetic individuality and heritability. The vast array of data collected from genome-wide association studies must now be empowered and explored through more complex interaction studies, using standardized methods and larger sample sizes. In doing so the etiology of chronic disease progression will be further understood.

https://pubmed.ncbi.nlm.nih.gov/21311326