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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.
Publication : Journal of physiology, Paris

Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors

Team: Signaling and receptors dynamics
Member: Pierre-Jean Corringer
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of physiology, Paris - 01 Apr 1998

Servent D, Thanh HL, Antil S, Bertrand D, Corringer PJ, Changeux JP, Ménez A

Link to Pubmed [PMID] – 9782452

J. Physiol. Paris 1998 Apr;92(2):107-11

Snakes and cone snails produce toxins which block muscular and/or neuronal nicotinic acetylcholine receptors (AChRs). This paper mostly focuses on the determinants by which a snake long chain curaremimetic toxin and the cone snail toxin ImI bind specifically to the alpha 7 neuronal receptor. In both cases, the site involves a small turn-like structure constrained by two half-cystines.