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Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites

Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation

© Thierry Blisnick & Philippe Bastin, Institut Pasteur

Bloodstream Trypanosoma brucei cell

Publication : BMC biotechnology

Functional complementation of RNA interference mutants in trypanosomes

Team: Trypanosome Cell Biology

Member: Philippe Bastin

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in BMC biotechnology - 09 Feb 2005

Rusconi F, Durand-Dubief M, Bastin P

Link to Pubmed [PMID] – 15703078

BMC Biotechnol. 2005;5:6

In many eukaryotic cells, double-stranded RNA (dsRNA) triggers RNA interference (RNAi), the specific degradation of RNA of homologous sequence. RNAi is now a major tool for reverse-genetics projects, including large-scale high-throughput screens. Recent reports have questioned the specificity of RNAi, raising problems in interpretation of RNAi-based experiments.

Published on: 09 Feb 2005