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© Research
Publication : Cerebral cortex

Functional and Structural Properties of Highly Responsive Somatosensory Neurons in Mouse Barrel Cortex.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cerebral cortex - 08 May 2021

Barz CS, Garderes PM, Ganea DA, Reischauer S, Feldmeyer D, Haiss F,

Link to Pubmed [PMID] – 33963394

Link to DOI – 10.1093/cercor/bhab104

Cereb Cortex 2021 May; ():

Sparse population activity is a well-known feature of supragranular sensory neurons in neocortex. The mechanisms underlying sparseness are not well understood because a direct link between the neurons activated in vivo, and their cellular properties investigated in vitro has been missing. We used two-photon calcium imaging to identify a subset of neurons in layer L2/3 (L2/3) of mouse primary somatosensory cortex that are highly active following principal whisker vibrotactile stimulation. These high responders (HRs) were then tagged using photoconvertible green fluorescent protein for subsequent targeting in the brain slice using intracellular patch-clamp recordings and biocytin staining. This approach allowed us to investigate the structural and functional properties of HRs that distinguish them from less active control cells. Compared to less responsive L2/3 neurons, HRs displayed increased levels of stimulus-evoked and spontaneous activity, elevated noise and spontaneous pairwise correlations, and stronger coupling to the population response. Intrinsic excitability was reduced in HRs, while we found no evidence for differences in other electrophysiological and morphological parameters. Thus, the choice of which neurons participate in stimulus encoding may be determined largely by network connectivity rather than by cellular structure and function.