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© Research
Publication : Annales d'immunologie

From the mechanisms of lymphocyte activation to internal activity in the immune system

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annales d'immunologie - 01 Jul 1983

Coutinho A, Bandeira A, Björklund M, Forni L, Forsgren S, Freitas AA, Gullberg M, Holmberg D, Ivars F, Larsson EL

Link to Pubmed [PMID] – 6226240

Ann. Immunol. (Paris) 1983 Jul-Aug;134D(1):93-102

The principles of lymphocyte activation were summarized for all three sets of immunocompetent cells: B cells, cytotoxic cells and helper T lymphocytes. They were then used to derive the basic mechanisms and specificities which drive internal activity in the normal immune system and which select available antibody repertoires. It was postulated that “natural antibodies” are induced by “natural helper cells” and are selected on the basis of their idiotypic profiles, which are complementary to available T-helper-cell repertoires. “Natural idiotypes” would then carry idiotopes similar to MHC epitopes, the predominant germ-line specificity of T-cell repertoires.

http://www.ncbi.nlm.nih.gov/pubmed/6226240