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© Research
Publication : Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

Foscarnet as salvage therapy in HIV-2-infected patient with antiretroviral treatment failure

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 03 Dec 2009

Stegmann S, Manea ME, Charpentier C, Damond F, Karmochkine M, Laureillard D, Si-Mohamed A, Weiss L, Piketty C

Link to Pubmed [PMID] – 19962343

J. Clin. Virol. 2010 Jan;47(1):79-81

Previous studies have suggested the efficacy of foscarnet combined with thymidine analogues as salvage therapy in late-stage HIV-1 infection. Here, we report on the first case of foscarnet therapy in a patient infected with HIV-2 exhibiting virologic failure. The patient was known to be HIV-2-infected since 1992 and had received 11 sequential lines of combined antiretroviral therapy (cART) with almost all the available antiretroviral agents including raltegravir. A marked decrease in HIV-2 plasma viral load of 1.48 log(10)copies/ml was observed at day 14 of foscarnet induction therapy associated with zidovudine and failing cART. An optimized cART was then introduced with lamivudine, zidovudine, lopinavir/r, etravirine and maraviroc. Four months after the end of foscarnet therapy, HIV-2 plasma viral load remained undetectable. This case report suggests that foscarnet may represent a therapeutic option for HIV-2-infected patients exhibiting multidrug resistance.

http://www.ncbi.nlm.nih.gov/pubmed/19962343