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© Research
Publication : Genes to cells : devoted to molecular & cellular mechanisms

Fission yeast chk1 mutants show distinct responses to different types of DNA damaging treatments

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Genes to cells : devoted to molecular & cellular mechanisms - 01 Jul 2002

Francesconi S, Smeets M, Grenon M, Tillit J, Blaisonneau J, Baldacci G

Link to Pubmed [PMID] – 12081644

Genes Cells 2002 Jul;7(7):663-73

Chk1 kinase is activated by phosphorylation at serine-345 by Rad3 checkpoint kinase and is required for DNA damage checkpoint in late S and G2 phase of S. pombe cell cycle. We studied the ability of two chk1 mutants, chk1-1 and chk1-2, to undergo phosphorylation and to delay cell cycle progression in response to different types of DNA lesions.