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© Research
Publication : The Biochemical journal

Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase

Member: Antonio Freitas
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Biochemical journal - 15 Feb 1979

Irvine RF, Letcher AJ, Dawson RM

Link to Pubmed [PMID] – 220968

Biochem. J. 1979 Feb;178(2):497-500

The hydrolysis of membrane-bound phosphatidylinositol in rat liver microsomal fraction by the soluble phosphatidylinositol phosphodiesterase from rat brain was markedly stimulated by oleic acid or arachidonic acid. The stimulation did not require added calcium, although it was abolished by EDTA. Lysophosphatidylcholine also totally suppressed the stimulation. A possible role for the fatty acid content of a membrane in controlling phosphatidylinositol turnover is suggested.