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© Research
Publication : Journal of clinical microbiology

Fatal-stroke syndrome revealing fungal cerebral vasculitis due to Arthrographis kalrae in an immunocompetent patient.

Reference Center: Invasive Mycoses and Antifungals
Member: Marie Desnos-Ollivier
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of clinical microbiology - 01 Sep 2008

Pichon N, Ajzenberg D, Desnos-Ollivier M, Clavel M, Gantier JC, Labrousse F,

Link to Pubmed [PMID] – 18650350

Link to DOI – 10.1128/JCM.00800-08

J Clin Microbiol 2008 Sep; 46(9): 3152-5

We report an uncommon clinical presentation of a unique case of fatal invasive fungal cerebral vasculitis due to Arthrographis kalrae in a nonimmunocompromised host. The identity of the fungus was determined by morphological characteristics and by analysis of internal transcribed spacer 1 sequences and was confirmed by postmortem examination of the brain tissues. Establishing rapidly the link between the clinical syndromes and the fungal infection of the central nervous system is essential to improve the outcome. As our case has shown, it is more challenging to make a diagnosis of fungal infection when there are no risk factors of immunodeficiency and when the clinical presentation seems uncommon.