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© Research
Publication : Proceedings of the National Academy of Sciences of the United States of America

Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 01 Jan 1991

Bandeira A, Itohara S, Bonneville M, Burlen-Defranoux O, Mota-Santos T, Coutinho A, Tonegawa S

Link to Pubmed [PMID] – 1986381

Proc. Natl. Acad. Sci. U.S.A. 1991 Jan;88(1):43-7

The kinetics of postnatal intestinal colonization by T cells carrying gamma delta and alpha beta T-cell antigen receptors were studied in nude and normal mice by flow cytometry and immunohistology. Furthermore, gamma delta and alpha beta T-cell development was analyzed in lethally irradiated mice that were reconstituted by fetal liver precursors with or without a thymus. Our results establish that a major subpopulation of gamma delta intestinal intraepithelial lymphocytes is produced from uncommitted precursors at extrathymic sites. This work further shows that a small pool of T cells carrying alpha beta T-cell receptors can also differentiate extrathymically from CD3- fetal liver precursors but with rates of production and peripheral expansion much reduced as compared with those observed in thymus-bearing animals.

http://www.ncbi.nlm.nih.gov/pubmed/1986381