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© Research
Publication : Nature

Expression of two myogenic regulatory factors myogenin and MyoD1 during mouse embryogenesis.

Team: Malaria Infection & Immunity
Team: Malaria Parasite Biology and Vaccines
Member: Margaret Buckingham
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature - 28 Sep 1989

Sassoon D, Lyons G, Wright WE, Lin V, Lassar A, Weintraub H, Buckingham M

Link to Pubmed [PMID] – 2552320

Nature 1989 Sep; 341(6240): 303-7

MyoD1 and myogenin are muscle-specific proteins which can convert non-myogenic cells in culture to differentiated muscle fibres, implicating them in myogenic determination. The pattern of expression of MyoD1 and myogenin during the early stages of muscle formation in the mouse embryo in vivo and in limb-bud explants cultured in vitro, indicates that they may have different functions in different types of muscle during development.