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© Research
Publication : Science (New York, N.Y.)

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

Team: Group: Humoral Immunity
Member: Paulo Vieira
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 01 Nov 1990

Hsu DH, de Waal Malefyt R, Fiorentino DF, Dang MN, Vieira P, de Vries J, Spits H, Mosmann TR, Moore KW

Link to Pubmed [PMID] – 2173142

Science 1990 Nov;250(4982):830-2

Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host’s immune system.