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© Research
Publication : BMC genomics

Evolution of major milk proteins in Mus musculus and Mus spretus mouse species: a genoproteomic analysis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC genomics - 28 Jan 2011

Boumahrou N, Bevilacqua C, Beauvallet C, Miranda G, Andrei S, Rebours E, Panthier JJ, Bellier S, Martin P

Link to Pubmed [PMID] – 21276224

BMC Genomics 2011;12:80

Due to their high level of genotypic and phenotypic variability, Mus spretus strains were introduced in laboratories to investigate the genetic determinism of complex phenotypes including quantitative trait loci. Mus spretus diverged from Mus musculus around 2.5 million years ago and exhibits on average a single nucleotide polymorphism (SNP) in every 100 base pairs when compared with any of the classical laboratory strains. A genoproteomic approach was used to assess polymorphism of the major milk proteins between SEG/Pas and C57BL/6J, two inbred strains of mice representative of Mus spretus and Mus musculus species, respectively.

http://www.ncbi.nlm.nih.gov/pubmed/21276224