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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Journal of cell science

Evidence that the tumor-suppressor protein BRCA2 does not regulate cytokinesis in human cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of cell science - 31 Mar 2010

Lekomtsev S, Guizetti J, Pozniakovsky A, Gerlich DW, Petronczki M

Link to Pubmed [PMID] – 20356927

J. Cell. Sci. 2010 May;123(Pt 9):1395-400

Germline mutations in the tumor-suppressor gene BRCA2 predispose to breast and ovarian cancer. BRCA2 plays a well-established role in maintaining genome stability by regulating homologous recombination. BRCA2 has more recently been implicated in cytokinesis, the final step of cell division, but the molecular basis for this remains unknown. We have used time-lapse microscopy, recently developed cytokinesis assays and BAC recombineering (bacterial artificial chromosome recombinogenic engineering) to investigate the function and localization of BRCA2 during cell division. Our analysis suggests that BRCA2 does not regulate cytokinesis in human cells. Thus, cytokinesis defects are unlikely to contribute to chromosomal instability and tumorigenesis in BRCA2-related cancers.

http://www.ncbi.nlm.nih.gov/pubmed/20356927