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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : Trends in cell biology

ESCRT-III polymers in membrane neck constriction

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in cell biology - 10 Jan 2012

Guizetti J, Gerlich DW

Link to Pubmed [PMID] – 22240455

Trends Cell Biol. 2012 Mar;22(3):133-40

The endosomal sorting complex required for transport (ESCRT)-III machinery contributes to membrane deformation and scission in cytokinesis, intraluminal vesicle formation, autophagy and virus budding. Recombinant ESCRT-III subunits polymerize in vitro into filaments, tubes, sheets or rings, and ESCRT-III-dependent filaments have been observed in cells at virus bud necks and at the cytokinetic abscission site. These observations have inspired speculation about how ESCRT-III could mediate constriction and fission of membrane necks. Based on the polymer structures observed in vitro and in vivo, we discuss models for ESCRT-III function and outline how emerging technologies could be used to test these models.

http://www.ncbi.nlm.nih.gov/pubmed/22240455