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© Research
Publication : Epidemiology and infection

Escherichia coli bacteraemia in adults: age-related differences in clinical and bacteriological characteristics, and outcome

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Epidemiology and infection - 20 Feb 2014

Roubaud Baudron C, Panhard X, Clermont O, Mentré F, Fantin B, Denamur E, Lefort A,

Link to Pubmed [PMID] – 24559489

Epidemiol. Infect. 2014 Dec;142(12):2672-83

To explore the specificities of Escherichia coli bacteraemia in the elderly, the demographic, clinical and bacteriological characteristics and in-hospital mortality rate of ‘young’ (18-64 years, n = 395), ‘old’ (65-79 years, n = 372) and ‘very old’ (⩾80 years, n = 284) adult patients of the multicentre COLIBAFI cohort study were compared. Clinical and bacteriological risk factors for death were jointly identified by logistic regression and multivariate analysis within each group. ‘Young’ and ‘old’ patients had more comorbidities than ‘very old’ patients (comorbidity score: 1·5 ± 1·3 and 1·6 ± 1·2 vs. 1·2 ± 1·2, respectively; P < 0·001), and were more frequently nosocomially infected (22·3% and 23·8% vs. 8·8%, respectively; P < 0·001). ‘Old’ patients had the poorest prognosis (death rate: 16·4% vs.10·4% for ‘young’ and 12·0% for ‘very old’ patients, respectively; P = 0·039). Risk factors for death were age group-specific, suggesting a host-pathogen relationship evolving with age.

http://www.ncbi.nlm.nih.gov/pubmed/24559489