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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : Trends in parasitology

Erythrocyte remodeling by Plasmodium falciparum gametocytes in the human host interplay

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in parasitology - 27 Mar 2015

Tibúrcio M, Sauerwein R, Lavazec C, Alano P

Link to Pubmed [PMID] – 25824624

Trends Parasitol. 2015 Jun;31(6):270-8

The spread of malaria critically relies on the presence of Plasmodium transmission stages – the gametocytes – circulating in the blood of an infected individual, which are taken up by Anopheles mosquitoes. A striking feature of Plasmodium falciparum gametocytes is their long development inside the erythrocytes while sequestered in the internal organs of the human host. Recent studies of the molecular and cellular remodeling of the host erythrocyte induced by P. falciparum during gametocyte maturation are shedding light on how these may affect the establishment and maintenance of sequestration of the immature transmission stages and the subsequent release and circulation of mature gametocytes in the peripheral bloodstream.

http://www.ncbi.nlm.nih.gov/pubmed/25824624