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© Research
Publication : Joint, bone, spine : revue du rhumatisme

Epigenetics and lupus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Joint, bone, spine : revue du rhumatisme - 15 Dec 2014

Miceli-Richard C

Link to Pubmed [PMID] – 25523441

Joint Bone Spine 2015 Mar;82(2):90-3

Systemic lupus erythematosus (SLE) is among the systemic autoimmune diseases whose complex pathogenesis involves both genetic and environmental factors. Epigenetic dysregulation resulting in overexpression of certain genes in some of the key immune cells, such as T cells, has been incriminated in the pathophysiology of SLE. Epigenetics is defined as transmissible and reversible modifications in gene expression without alterations in the nucleotide sequences. Epigenetic information is carried chiefly by DNA itself, histones, and noncoding RNAs. Several epigenetic mechanisms may play a role in SLE pathogenesis. This review discusses the various epigenetic mechanisms that regulate gene expression and provides examples relevant to SLE.

https://www.ncbi.nlm.nih.gov/pubmed/25523441