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© Research
Publication : Journal of virology

Enhanced gene silencing in cells cured of persistent virus infection by RNA interference

Team: Archived: Innovation lab : vaccines
Team: Archived: Biology of Enteric Viruses
Member: Frédéric Tangy
Member: Isabelle Pelletier-Doucement
Member: Bruno Blondel
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 14 Apr 2010

Pelletier I, Saulnier A, Brisac C, Jegouic S, Vabret N, Tangy F, Blondel B, Colbère-Garapin F

Link to Pubmed [PMID] – 20392843

J. Virol. 2010 Jul;84(13):6880-5

We compared HEp-2-derived cells cured of persistent poliovirus infection by RNA interference (RNAi) with parental cells, to investigate possible changes in the efficiency of RNAi. Lower levels of poliovirus replication were observed in cured cells, possibly facilitating virus silencing by antiviral small interfering RNAs (siRNAs). However, green fluorescent protein (GFP) produced from a measles virus vector and also GFP and luciferase produced from plasmids that do not replicate in human cells were more effectively silenced by specific siRNAs in cured than in control cells. Thus, cells displaying enhanced silencing were selected during curing by RNAi. Our results strongly suggest that the RNAi machinery of cured cells is more efficient than that of parental cells.