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© Michel Huerre
Coupe histologique de foie de patient atteint d'une hépatite C chronique active avec infiltrat (opacité) folliculaire (lymphocytes) (Grossissement X 400). L'hépatite C chronique peut être à l'origine de cirrhose et cancer du foie
Publication : Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 02 Mar 2017

Briand FX, Schmitz A, Ogor K, Le Prioux A, Guillou-Cloarec C, Guillemoto C, Allée C, Le Bras MO, Hirchaud E, Quenault H, Touzain F, Cherbonnel-Pansart M, Lemaitre E, Courtillon C, Gares H, Daniel P, Fediaevsky A, Massin P, Blanchard Y, Eterradossi N, van der Werf S, Jestin V, Niqueux E

Link to Pubmed [PMID] – 28277218

Euro Surveill. 2017 Mar;22(9)

Several new highly pathogenic (HP) H5 avian influenza virus (AIV) have been detected in poultry farms from south-western France since November 2015, among which an HP H5N1. The zoonotic potential and origin of these AIVs immediately became matters of concern. One virus of each subtype H5N1 (150169a), H5N2 (150233) and H5N9 (150236) was characterised. All proved highly pathogenic for poultry as demonstrated molecularly by the presence of a polybasic cleavage site in their HA protein – with a sequence (HQRRKR/GLF) previously unknown among avian H5 HPAI viruses – or experimentally by the in vivo demonstration of an intravenous pathogenicity index of 2.9 for the H5N1 HP isolate. Phylogenetic analyses based on the full genomes obtained by NGS confirmed that the eight viral segments of the three isolates were all part of avian Eurasian phylogenetic lineage but differed from the Gs/Gd/1/96-like lineage. The study of the genetic characteristics at specific amino acid positions relevant for modulating the adaptation to and the virulence for mammals showed that presently, these viruses possess most molecular features characteristic of AIV and lack some major characteristics required for efficient respiratory transmission to or between humans. The three isolates are therefore predicted to have no significant pandemic potential.

https://www.ncbi.nlm.nih.gov/pubmed/28277218