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© Perrine Bomme, Guillaume Duménil, Jean-Marc Panaud.
Coloured scanning electron micrograph (SEM) of Neisseria meningitidis on epithelial cells
Publication : Expert opinion on emerging drugs

Emerging drugs for acute bacterial meningitis.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Expert opinion on emerging drugs - 01 Sep 2009

Deghmane AE, Alonso JM, Taha MK,

Link to Pubmed [PMID] – 19624284

Link to DOI [DOI] – 10.1517/14728210903120887

Expert Opin Emerg Drugs 2009 Sep; 14(3): 381-93

The management of acute bacterial meningitis is based on early antibiotic treatment to prevent unfavorable outcome (death and permanent sequelae). beta-Lactam antibiotics, particularly third-generation cephalosporins, are effective against most agents of community-acquired acute bacterial meningitis. Resistance to beta-lactams evolves, particularly in Streptococcus pneumoniae, that may lead to treatment failure. Evaluation of other antibiotics such as fourth-generation cephalosporin, new penems and quinolones is warranted. Adjunctive therapy aims to reduce tissue injuries provoked by the inflammatory response. The use of dexamethasone is still a matter of debate, but seems to be helpful under conditions of rapid etiological diagnosis and prompt management. Other drugs that neutralize bacterial factors or host mechanisms involved in induction of inflammatory response are under development.

https://pubmed.ncbi.nlm.nih.gov/19624284