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© Research
Publication : The Journal of infectious diseases

Emergence of new virulent Neisseria meningitidis serogroup C sequence type 11 isolates in France

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 15 Jul 2010

Deghmane AE, Parent du Chatelet I, Szatanik M, Hong E, Ruckly C, Giorgini D, Lévy-Bruhl D, Alonso JM, Taha MK

Link to Pubmed [PMID] – 20515410

J. Infect. Dis. 2010 Jul;202(2):247-50

In France, there have been variations in the incidence of invasive meningococcal infection due to serogroup C isolates. Infection peaks were observed in 1992 and 2003 that involved isolates of phenotypes C:2a:P1.5,2 and/or C:2a:P1.5, which belong to the sequence type 11 (ST-11) clonal complex. We report an emergence of isolates belonging to the ST-11 clonal complex since 2003. These isolates displayed a new phenotype, C:2a:P1.7,1, caused infections that occurred as clusters, and were associated with increased infection severity and high virulence in mice. These isolates may be responsible for a peak in the incidence of serogroup C meningococcal infection in France, for which there is no routine vaccination to date.

http://www.ncbi.nlm.nih.gov/pubmed/20515410