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© Research
Publication : Emerging infectious diseases

Emergence of New Non-Clonal Group 258 High-Risk Clones among Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae Isolates, France.

Team: Ecology and Evolution of Antibiotics Resistance
Member: Philippe Glaser
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Emerging infectious diseases - 01 Jun 2020

Bonnin RA, Jousset AB, Chiarelli A, Emeraud C, Glaser P, Naas T, Dortet L,

Link to Pubmed [PMID] – 32441629

Link to DOI – 10.3201/eid2606.191517

Emerg Infect Dis 2020 06; 26(6): 1212-1220

The worldwide spread of Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) isolates was reported to be caused by dissemination of 1 clonal complex (i.e., clonal group [CG] 258, which includes sequence types [STs] 258 and 512). We conducted whole-genome sequencing and epidemiologic analysis of all KPC-Kp isolates in France in 2018 and found that new successful high-risk clones of ST147, ST307, ST231, and ST383 are now the main drivers of blaKPC genes. The blaKPC genes were mostly carried by Tn4401a and Tn4401d structures and a new non-Tn4401 element. Our epidemiologic investigations showed that the emergence of these non-CG258 KPC-Kp isolates in France was linked to dissemination of these clones from Portugal. Thus, KPC-Kp epidemiology has changed in Europe, at least in several non-KPC-endemic countries of western Europe, such as France and Portugal, where CG258 is not the most prevalent clone.