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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell
Publication : Médecine sciences : M/S

[Elongation of the axoneme and dynamics of intraflagellar transport]

Team: Trypanosome Cell Biology
Member: Philippe Bastin
Member:
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Médecine sciences : M/S - 10 Nov 2014

Fort C, Bastin P

Link to Pubmed [PMID] – 25388576

Med Sci (Paris) 2014 Nov;30(11):955-61

Cilia and flagella are essential organelles in most eukaryotes including human beings. In this review, we will discuss the mode of assembly of these complex organelles that depends on a dynamic process called intraflagellar transport or IFT. IFT delivers structural elements at the distal end of the cilium where assembly takes place, thereby allowing the growth of the organelle. We next discuss the different models for control of cilium length and their alterations in ciliopathies, genetic diseases associated to ciliary defects.