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© Research
Publication : The Journal of comparative neurology

Electron tomographic analysis of synaptic ultrastructure.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of comparative neurology - 15 Aug 2012

Burette AC, Lesperance T, Crum J, Martone M, Volkmann N, Ellisman MH, Weinberg RJ,

Link to Pubmed [PMID] – 22684938

Link to DOI – 10.1002/cne.23067

J Comp Neurol 2012 Aug; 520(12): 2697-711

Synaptic function depends on interactions among sets of proteins that assemble into complex supramolecular machines. Molecular biology, electrophysiology, and live-cell imaging studies have provided tantalizing glimpses into the inner workings of the synapse, but fundamental questions remain regarding the functional organization of these “nano-machines.” Electron tomography reveals the internal structure of synapses in three dimensions with exceptional spatial resolution. Here we report results from an electron tomographic study of axospinous synapses in neocortex and hippocampus of the adult rat, based on aldehyde-fixed material stabilized with tannic acid in lieu of postfixation with osmium tetroxide. Our results provide a new window into the structural basis of excitatory synaptic processing in the mammalian brain.

https://pubmed.ncbi.nlm.nih.gov/22684938