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© Research
Publication : Journal of structural biology

Electron cryo-tomography of vestibular hair-cell stereocilia.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of structural biology - 01 May 2019

Metlagel Z, Krey JF, Song J, Swift MF, Tivol WJ, Dumont RA, Thai J, Chang A, Seifikar H, Volkmann N, Hanein D, Barr-Gillespie PG, Auer M,

Link to Pubmed [PMID] – 30822456

Link to DOI – S1047-8477(19)30029-210.1016/j.jsb.2019.02.006

J Struct Biol 2019 05; 206(2): 149-155

High-resolution imaging of hair-cell stereocilia of the inner ear has contributed substantially to our understanding of auditory and vestibular function. To provide three-dimensional views of the structure of stereocilia cytoskeleton and membranes, we developed a method for rapidly freezing unfixed stereocilia on electron microscopy grids, which allowed subsequent 3D imaging by electron cryo-tomography. Structures of stereocilia tips, shafts, and tapers were revealed, demonstrating that the actin paracrystal was not perfectly ordered. This sample-preparation and imaging procedure will allow for examination of structural features of stereocilia in a near-native state.

https://pubmed.ncbi.nlm.nih.gov/30822456