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Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs

Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages

© Giulia Manina, Institut Pasteur

Mycobacterium tuberculosis dual fluorescent reporter of metabolic activity. Green (active bacilli) and red fluorescence (quiescent bacilli) are merged, 100X magnification.

Publication : BMC microbiology

Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome

Team: Microbial Individuality and Infection

Member: Giulia Manina

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in BMC microbiology - 20 Jul 2006

Guglierame P, Pasca MR, De Rossi E, Buroni S, Arrigo P, Manina G, Riccardi G

Link to Pubmed [PMID] – 16857052

BMC Microbiol. 2006;6:66

Burkholderia cenocepacia is recognized as opportunistic pathogen that can cause lung infections in cystic fibrosis patients. A hallmark of B. cenocepacia infections is the inability to eradicate the organism because of multiple intrinsic antibiotic resistance. As Resistance-Nodulation-Division (RND) efflux systems are responsible for much of the intrinsic multidrug resistance in Gram-negative bacteria, this study aims to identify RND genes in the B. cenocepacia genome and start to investigate their involvement into antimicrobial resistance.

Published on: 20 Jul 2006