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© Research
Publication : The American journal of tropical medicine and hygiene

Effects of malnutrition on children’s immunity to bacterial antigens in Northern Senegal

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The American journal of tropical medicine and hygiene - 20 Jan 2014

Gaayeb L, Sarr JB, Cames C, Pinçon C, Hanon JB, Ndiath MO, Seck M, Herbert F, Sagna AB, Schacht AM, Remoue F, Riveau G, Hermann E

Link to Pubmed [PMID] – 24445198

Am. J. Trop. Med. Hyg. 2014 Mar;90(3):566-73

To evaluate immunity to vaccine-preventable diseases according to nutritional status, a longitudinal study was conducted in Senegalese children ages 1-9 years old. A linear regression analysis predicted that weight for age was positively associated with immunoglobulin G (IgG) response to tetanus toxoid in children born during the rainy season or at the beginning of the dry season. A relationship between village, time of visits, and levels of antibodies to tetanus showed that environmental factors played a role in modulating humoral immunity to tetanus vaccine over time. Moreover, a whole-blood stimulation assay highlighted that the production of interferon-γ (IFN-γ) in response to tetanus toxoid was compromised in stunted children. However, the absence of cytokine modulation in response to Mycobacterium tuberculosis-purified protein derivatives and phytohemagglutinin suggests that the overall ability to produce IFN-γ was preserved in stunted children. Therefore, these results show that nutritional status can specifically alter the efficacy of long-lasting immunity to tetanus.

http://www.ncbi.nlm.nih.gov/pubmed/24445198